Immunodeficiency clinical trials at UCSF
23 in progress, 13 open to eligible people
Abatacept for the Treatment of Common Variable Immunodeficiency With Interstitial Lung Disease
open to eligible people ages 4 years and up
There is no standard of care therapy for patients with granulomatous-lymphocytic interstitial lung disease (GLILD) seen in common variable immunodeficiency (CVID). Abatacept has recently looked promising for the treatment of patients with complex…
San Francisco, California and other locations
Adenovirus-specific Cytotoxic T-lymphocytes for Refractory Adenovirus Infection
open to eligible people ages 1 month to 79 years
Related donor Adenovirus (ADV) specific cytotoxic T cells (CTLs) manufactured with the Miltenyi CliniMACS Prodigy Cytokine Capture System will be administered intravenously in in children, adolescents and young adults with refractory ADV infection…
San Francisco, California and other locations
Autologous Gene Therapy for Artemis-Deficient SCID
open to eligible people ages 2 months and up
This study aims to determine if a new method can be used to treat Artemis-deficient Severe Combined Immunodeficiency (ART-SCID), a severe form of primary immunodeficiency caused by mutations in the DCLRE1C gene. This method involves transferring a…
San Francisco, California
CAR-T Cells for HIV Infection
open to eligible people ages 18-65
This is a limited-center, open-label dose escalating phase I/IIa study of autologous T cells expressing LVgp120duoCAR molecules in people with HIV infection. It will follow a 3+3 design. Dose escalation decisions will be made when a minimum of three …
San Francisco, California and other locations
Conditioning SCID Infants Diagnosed Early
open to eligible people ages 0-2
The investigators want to study if lower doses of chemotherapy will help babies with SCID to achieve good immunity with less short and long-term risks of complications after transplantation. This trial identifies babies with types of immune…
San Francisco, California and other locations
EBV-specific Cytotoxic T-lymphocytes (CTLs) for Refractory EBV Infection
open to eligible people ages 1 month to 79 years
Related donor Epstein-Barr Virus (EBV) specific cytotoxic T cells (CTLs) manufactured with the Miltenyi CliniMACS Prodigy Cytokine Capture System will be administered in children, adolescents and young adults with refractory EBV infection post…
San Francisco, California and other locations
PCSK9 Inhibition on Cardiovascular Risk in Treated HIV Infection (EPIC-HIV Study)
open to eligible people ages 40 years and up
Atherosclerosis in the setting of HIV infection is distinct and includes increased vascular inflammation, worsened endothelial function, and a predominance of non-calcified plaque. These outcomes can be assessed using specialized noninvasive imaging …
San Francisco, California
Imaging Immune Activation in HIV by PET-MR
open to eligible people ages 18 years and up
This is a single center exploratory imaging study involving one intravenous microdose of [18F]F-AraG followed by whole-body positron emission tomography-magnetic resonance (PET-MR) imaging in HIV infected individuals to determine the anatomical…
San Francisco, California
SCOPE Analytic Treatment Interruption Protocol
open to eligible people ages 18 years and up
The goal of this study is to understand the interaction between HIV and the host at the earliest stages when HIV medications are paused. Volunteers with HIV will interrupt antiretroviral therapy (ART) and then have intensive studies preformed two to …
San Francisco, California
Text Education About Cardiovascular Health and HIV (TEACH-HIV)
open to eligible people ages 40 years and up
The overall objective is to evaluate the efficacy of educational text messages to reduce cardiovascular risk among persons living with HIV (PLWH).
San Francisco, California and other locations
Treatment of Refractory BK Infections With Related Donor BK Specific Cytotoxic T-cells (CTLs)
open to eligible people ages 1 month to 79 years
BK cytotoxic T cells (CTLs) manufactured with the Miltenyi CliniMACS Prodigy Cytokine Capture System will be safe and effective in decreasing specific viral load in children, adolescents and young adults (CAYA) with refractory BK infection post…
San Francisco, California and other locations
Virus Specific Cytotoxic T-Lymphocytes (CTLs) for Refractory Cytomegalovirus (CMV)
open to eligible people ages 1 month to 79 years
CMV cytotoxic T cells (CTLs) manufactured with the Miltenyi CliniMACS Prodigy Cytokine Capture System will be administered in children, adolescents and young adults (CAYA) with refractory cytomegalovirus (CMV) infection post Allogeneic Hematopoietic …
San Francisco, California and other locations
Anal High-risk HPV, HSIL, and Microbiome Among Hispanic Peoples Living With HIV (PLWH)
open to eligible people ages 21 years and up
The study evaluates if there is relationship between the kinds of bacteria living in the anus (also known as the anal microbiome) and the risk of human papillomavirus (HPV) infection or HPV-related pre-cancer (high-grade squamous intraepithelial…
San Francisco, California and other locations
Gene Transfer for X-Linked Severe Combined Immunodeficiency in Newly Diagnosed Infants
Sorry, currently not accepting new patients, but might later
SCID-X1 is a genetic disorder of blood cells caused by DNA changes in a gene that is required for the normal development of the human immune system. The purpose of this study is to determine if a new method, called lentiviral gene transfer, can be…
San Francisco, California and other locations
Combination HIV-Specific Broadly Neutralizing Monoclonal Antibodies Combined With ART Initiation During Acute HIV Infection to Induce HIV Remission
Sorry, not currently recruiting here
A5388 is a phase II, two-arm, randomized, double-blind, placebo-controlled study that will enroll 48 antiretroviral therapy (ART)-naïve adults with acute HIV infection (AHI) in order to determine whether: - Administration of combination HIV-specific …
San Francisco, California and other locations
Switch to Doravirine/Islatravir (DOR/ISL) in Participants With Human Immunodeficiency Virus Type 1 (HIV-1) Who Are Virologically Suppressed on Antiretroviral Therapy (ART) (MK-8591A-051)
Sorry, in progress, not accepting new patients
The primary objectives of this study are to evaluate the safety and tolerability of a switch to Doravirine/Islatravir (DOR/ISL) compared with continued baseline antiretroviral therapy (ART), through Week 48; and to evaluate the antiretroviral…
San Francisco, California and other locations
Combinatorial Therapy to Induce an HIV Remission
Sorry, in progress, not accepting new patients
Combination approaches will almost certainly be required to generate durable control of HIV in the absence of antiretroviral therapy (a "remission"). In this study, 20 individuals will receive a combination regimen administered during ART and then…
San Francisco, California
Gene Therapy in Treating Patients With Human Immunodeficiency Virus-Related Lymphoma Receiving Stem Cell Transplant
Sorry, in progress, not accepting new patients
This phase I/II trial studies the side effects and best dose of gene therapy in treating patients with human immunodeficiency virus (HIV)-related lymphoma that did not respond to therapy or came back after an original response receiving stem cell…
San Francisco, California and other locations
JSP191 Antibody Targeting Conditioning in SCID Patients
Sorry, in progress, not accepting new patients
A Phase 1/2 study to evaluate the safety, tolerability, and efficacy of an antibody conditioning regimen, known as JSP191, in patients with Severe Combined Immune Deficiency undergoing blood stem cell transplantation
San Francisco, California and other locations
LetSync: Pilot Test of Mobile Health (mHealth) Intervention
Sorry, in progress, not accepting new patients
The Pilot Test (AKA Study B) will entail a pilot randomized, controlled trial (RCT) of an mHealth behavioral intervention, LetSync, with 80 couples (N=160) to assess its acceptability, feasibility, and preliminary impact on retention in care and ART …
San Francisco, California
Surgery in Treating Patients With Early Stage Anal Canal or Perianal Cancer and HIV Infection
Sorry, in progress, not accepting new patients
This phase II trial studies surgery in treating patients with anal canal or perianal cancer that is small and has not spread deeply into the tissues and human immunodeficiency virus (HIV) infection. Local surgery may be a safer treatment with fewer…
San Francisco, California and other locations
Immunogenicity of a Modified Vaccinia Ankara (MVA)-Based Anti-Cytomegalovirus (CMV) Vaccine (Triplex®)
Sorry, in progress, not accepting new patients
Participants will be randomized in a 2:1 ratio to receive either two injections of CMV-MVA Triplex® or placebo administered at study Entry/Day 0 and week 4. Vaccine Group: 60 participants will receive CMV-MVA Triplex® containing 5 x 10^8…
San Francisco, California and other locations
Natural History Study of SCID Disorders
Sorry, accepting new patients by invitation only
This study is a prospective evaluation of children with Severe Combined Immune Deficiency (SCID) who are treated under a variety of protocols used by participating institutions. In order to determine the patient, recipient and transplant-related…
San Francisco, California and other locations
Our lead scientists for Immunodeficiency research studies include Priscilla Hsue Julia Chu, MD Steven Deeks, MD Michele Pham, MD Timothy J Henrich, MD Christopher Dvorak Megan McLaughlin Morton Cowan Chia-Ching Wang Joel Palefsky, MD Judy Y Tan, Ph.D..
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