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Eligibility
for people ages 25 years to 65 years
Healthy Volunteers
healthy people welcome
Location
at San Francisco, California
Dates
study started
estimated completion:
Principal Investigator

Description

Summary

Obesity affects over one third of US adults (>72 million, with BMI ≥30 kg/m2), and the proportion of US adults with BMI ≥40 kg/m2 has doubled in the last 20 years. Obesity is associated with increased mortality through its linkage to comorbidities including diabetes, hypertension, dyslipidemia, osteoarthritis, sleep apnea and psychosocial disturbances. Given its prevalence, impact on morbidity and mortality, and economic cost, limiting the spread of obesity and its consequences is one of the most important problems of our time.

Official Title

Development of a Multi-Ethnic, Multimodal Obesity Cohort

Details

The Inflammation, Diabetes, Ethnicity and Obesity (IDEO) cohort is recruiting 145 lean and obese individuals from three ethnicities, covering a spectrum of obesity and T2DM risk. Specifically, the cohort will include: 1) 45 obese subjects, including individuals each from three ethnic groups; Caucasian, Hispanic/Latino, and Chinese; 2) 45 subjects who are slated to undergo any type of bariatric surgery for obesity (20 individuals each from the three ethnic groups above); and 3) 55 lean controls, including individuals from each ethnicity.

Keywords

Obesity Diabetes Mellitus ethnicity inflammation

Eligibility

You can join if…

Open to people ages 25 years to 65 years

  • Subjects defined (lean and obese) from three defined ethnic groups; Caucasian,Hispanic/Latino, and Chinese.
  • Subjects will be between the ages of 25-65 years. These cutoffs are designed to allow inclusion of postmenopausal women, and younger/more active patients who are increasingly undergoing bariatric surgery.
  • BMI criteria for both surgical and nonsurgical obese patients and lean "controls" are as follows: Obese patients: BMI> 30 with standard comorbidities. For Chinese individual BMI cutoff for obesity is>27. Lean controls: BMI < 30 but BMI>18.5
  • Patients with either diabetes type 2 or the metabolic syndrome will be included in the cohort.

You CAN'T join if...

  • Subjects with chronic kidney disease (> stage 3), chronic infections, autoimmune diseases.
  • Subjects with symptomatic heart failure or CAD, cirrhosis or liver failure.
  • Tobacco abuse
  • Subjects on glucocorticoids, immunosuppressants [ tacrolimus, cellcept] and PPAR-gamma agonist will be excluded from the study.

Location

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Francisco
Links
http://koliwadlab.ucsf.edu/ideo-obesity-cohort-0
ID
NCT03022682
Lead Scientist
Suneil Koliwad
Study Type
Observational
Last Updated
January 2017
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