a study on Pain
This study evaluates invasive deep brain stimulation (DBS) in the treatment of chronic neuropathic pain. Half of the participants will be assigned to a group with recording / stimulation to one pain-related circuit of the brain while the other half of participants will be assigned to recording / stimulation to a different pain-related circuit of the brain. Relief of pain symptoms with stimulation will be studied in both groups. It is hypothesized that neural signals will correlate with pain states and that DBS can disrupt these pain states in both groups.
Deep Brain Stimulation (DBS) in Patients With Refractory Chronic Neuropathic Pain
The purpose of this study is to test the efficacy of DBS in a small cohort of patients with chronic pain refractory to conventional treatments. The study will involve the implantation of a neurostimulator, the Medtronic Activa PC+S device, to examine the efficacy of two modes of DBS. Open-loop DBS will provide stimulation based on a pre-set schedule, whereas closed-loop DBS will deliver stimulation based on brain activity associated with pain states. The goals of this study are to identify neurophysiological correlates of elevated pain states and find DBS parameters that disrupt pain-related brain activity and provide pain relief with little or no side effects. The efficacy of site-specific stimulation will also be studied.
Chronic Neuropathic Pain
Open to people ages 21 years and up
We will not share your information with anyone other than the team in charge of this study. Submitting your contact information does not obligate you to participate in research.
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If you do not hear from the study team, please call 888-689-8273 and tell them you’re interested in study number NCT03029884.
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