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Summary

for people ages 50–95 (full criteria)
healthy people welcome
at Yountville, California and other locations
study started
estimated completion:

Description

Summary

The objective of this study is to measure the frequency and clinical types of mild cognitive impairment (MCI) or dementia that occur among up to 150 military retirees with and without a history of traumatic brain injury (TBI) among residents of the Armed Forces Retirement Home, Washington D.C. and the Veterans Home of California-Yountville. Investigators will compare the characteristics of dementia in those who have had a prior TBI to the characteristics in those without a history of TBI. It is our hypothesis that the dementia or MCI among those with prior TBI has distinct neuropsychological features that distinguishes it from those with dementia or MCI without a history of TBI.

Official Title

Endophenotypes of Dementia Associated With Traumatic Brain Injury in Retired Military Personnel

Details

75 participants with a history of TBI will be the cases (exposed) group. A control group of 75 retirement home residents without a history of TBI who are age-matched to the cases will also be recruited. Participants will be evaluated in a single visit, which will include neurological, psychiatric, and cognitive assessment. The evaluation will take approximately 4 hours. In some cases, the evaluation may be split into two 2 hour sessions.

Keywords

Dementia Traumatic Brain Injury (TBI) Mild Cognitive Impairment (MCI) Chronic Traumatic Encephalopathy (CTE) Post-traumatic Stress Disorder (PTSD) Remote effects of TBI Post-traumatic stress disorder (PTSD_ Wounds and Injuries Brain Injuries Stress Disorders, Traumatic Brain Injuries, Traumatic Cognitive Dysfunction Stress Disorders, Post-Traumatic Brain Diseases Chronic Traumatic Encephalopathy

Eligibility

You can join if…

Open to people ages 50–95

Cases (with a history of TBI):

  1. Ages 50-95 years
  2. History of traumatic brain injury of sufficient severity to have resulted in medical attention (ascertained via the Ohio State University TBI Identification Questionnaire—OSU TBI-ID, and based on DoD/VA criteria)
  3. Residence in AFRH-Washington D.C. or the Veterans Home of California-Yountville
  4. MMSE score ≥ 20
  5. Capacity to provide consent to participate in research (assessment made by study physician)
  6. Ability to read and write English

Controls (without a history of TBI):

  1. Ages 50-95 years
  2. No history of traumatic brain injury of sufficient severity to have resulted in medical attention (ascertained via the Ohio State University TBI Identification Questionnaire—OSU TBI-ID)
  3. Residence in AFRH-Washington or the Veterans Home of California-Yountville
  4. MMSE score ≥ 20
  5. Capacity to provide consent or assent to participate in research
  6. Ability to read and write English -

You CAN'T join if...

Cases (with a history of TBI):

  1. History of penetrating brain injury
  2. History of disabling neurological or psychiatric condition such as epilepsy (besides posttraumatic epilepsy), multiple sclerosis, cortical stroke, hypoxic-ischemic encephalopathy, encephalitis, or schizophrenia

Controls (without a history of TBI):

History of disabling neurological or psychiatric condition such as epilepsy, multiple sclerosis, cortical stroke, hypoxic-ischemic encephalopathy, encephalitis, or schizophrenia

Locations

  • California Veterans Home-Yountville accepting new patients
    Yountville, California, 94599, United States
  • Armed Forces Retirement Home in progress, not accepting new patients
    Washington D.C., District of Columbia, 20011-8400, United States

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Uniformed Services University of the Health Sciences
ID
NCT01891383
Lead Scientist
Kristine Yaffe
Study Type
Observational
Last Updated
December 2015
I’m interested in this study!