Summary

Healthy Volunteers
healthy people welcome
Location
at San Francisco, California and other locations
Dates
study started
completion around

Description

Summary

Primary progressive aphasia (PPA) is a disorder characterized by gradual decline in speech-language ability caused by underlying neurodegenerative disease. PPA is a devastating condition that can affect adults as young as their 50's, depriving them of the ability to communicate and function in society. Along with Alzheimer's Disease and other Alzheimer's Disease Related Dementias (AD/ADRD), PPA is now identified earlier and with greater precision. Increasingly, patients and families seek options for behavioral and neuromodulatory treatments to address PPA's devastating effects on communication, prolong speech-language skills, and maximize quality of life. Studies have documented the robust benefits of speech-language telerehabilitation methods for persons with PPA, with in-home treatment resulting in immediate and long-term benefits. This investigation aims to further enhance the potency of these treatment approaches by pairing them with tailored neuromodulatory intervention that targets critical brain networks supporting treatment in each clinical subtype of PPA. The study will evaluate the feasibility and preliminary benefit of home-based transcranial direct current stimulation (tDCS) combined with evidence-based speech-language telerehabilitation methods. tDCS will be delivered to patients in their own homes and site of stimulation will be tailored for each clinical subtype of PPA. This project has the potential to enhance clinical management and rehabilitation for individuals with PPA by establishing the benefit of behavioral and neuromodulatory treatment that is neurobiologically-motivated and accessible for patients and families.

Official Title

Telerehabilitation with Remotely-Supervised TDCS in Progressive Aphasia

Keywords

Primary Progressive Aphasia, Speech-Language Pathology, Fronto-Temporal Dementia, Alzheimer's Disease, Neurodegenerative Disease, Logopenic, Semantic, Nonfluent, Logopenic Variant Primary Progressive Aphasia, Semantic Variant Primary Progressive Aphasia, Nonfluent Variant Primary Progressive Aphasia, Semantic Dementia, Speech Entrainment, Script Training, Teletherapy, Transcranial Direct Current Stimulation, Remotely-Supervised Transcranial Direct Current Stimulation, Lexical Retrieval, Noninvasive Brain Stimulation, Telehealth, Aphasia, Pick Disease of the Brain, Frontotemporal Dementia, Remotely supervised Transcranial Direct Current Stimulation (RS-tDCS), Lexical Retrieval Training (LRT), Video Implemented Script Training in Aphasia (VISTA), RS-LRT, RS-VISTA

Eligibility

Locations

  • Memory and Aging Center, UCSF
    San Francisco California 94158 United States
  • University of Texas
    Austin Texas 78712 United States

Details

Status
in progress, not accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of Texas at Austin
Links
University of Texas Aphasia Research and Treatment Lab UCSF Language Neurobiology Lab
ID
NCT05901233
Study Type
Interventional
Participants
Expecting 10 study participants
Last Updated