Depression clinical trials at UCSF
30 in progress, 20 open to eligible people
Closed Loop, Doctor to Patient, Mobile Application for Depression in People With Multiple Sclerosis
open to eligible people ages 18-80
The researchers want to find out if an electronic application called MS CATCH can enhance patients' and doctors' experiences during and in between clinical visits. MS CATCH is a smartphone-based tool which allows patients to enter their mood related …
San Francisco, California
Better Sleep Study
open to eligible people ages 12-18
The overall aim of this proposal is a confirmatory efficacy trial sufficiently powered and designed to test the hypothesis that improving the relationship between biological circadian timing and waketime, a novel modifiable target, improves…
San Francisco, California
Biomarkers of Depression and Treatment Response
open to eligible people ages 18-70
This study is a stratified, parallel-group, single-center study utilizing multimodal imaging techniques to identify biomarkers for Major Depressive Disorder (MDD). The study goal is to identify biomarkers for MDD and treatment response that can be…
San Francisco, California
Building Resilience for Surgical Recovery
open to eligible people ages 65 years and up
The goal of this clinical trial is to test problem solving therapy (PST) in older adults who are undergoing major surgery. The main question it aims to answer is: What is the feasibility and acceptability of delivering PST to older surgical patients …
San Francisco, California
Cellular Aging and Neurobiology of Depression Study
open to eligible people ages 21-60
We are conducting an eight week longitudinal study to learn if blood levels of certain naturally occurring compounds and genetic markers differ between patients with depression and healthy adults who are not depressed, and if any such differences…
San Francisco, California
Closed-Loop Deep Brain Stimulation for Major Depression
open to eligible people ages 22-70
Neurons are specialized types of cells that are responsible for carrying out the functions of the brain. Neurons communicate with electrical signals. In diseases such as major depression this electrical communication can go awry. One way to change…
San Francisco, California
Diet and Depression
open to eligible people ages 18-80
This study is a pilot open label crossover trial to assess the feasibility and acceptability of reducing ultra- processed foods (UPF) in a personalized manner from the diets of patients with major depressive disorder who eat a large percentage of…
San Francisco, California
Engaging Mothers & Babies; Reimagining Antenatal Care for Everyone (EMBRACE) Study
open to eligible females
This is a randomized comparative effectiveness study of two forms of enhanced prenatal care among 657 Medi-Cal eligible pregnant individuals in Fresno, California. The goal is to see whether group prenatal care with wrap around services versus…
San Francisco, California and other locations
Ketamine for Veterans With Parkinson's Disease
open to eligible people ages 40-80
Parkinson's disease (PD) is a devastating illness that has a growing impact on Veterans. One of the most disabling symptoms is depression, which is common in PD and linked to poor quality of life and higher risk of suicide. Unfortunately, there is a …
San Francisco, California
Near Infrared Spectroscopy (NIRS) for Assessment of Depression
open to eligible people ages 18 years and up
Develop a NIRSIT testing protocol that can be administered in the diagnostic setting and reliably distinguishes the symptoms and severity of depression, with the help of repeated measure (up to five visits per subject) comparison of patients being…
San Francisco, California
Neural Mechanisms of Meditation Training in Healthy and Depressed Adolescents: An MRI Connectome Study PART 2
open to eligible people ages 14-18
The primary objective will be to study changes in putamen connectivity and depression severity in depressed teens with meditation training. H1: Putamen node strength will increase in the training group compared to the active controls. H2: This…
San Francisco, California
Perinatal Research on Improving Sleep and Mental Health
open to eligible females ages 18 years and up
The goal of this clinical trial is to compare two sleep programs in pregnant people with insomnia. The main questions it aims to answer are: 1. What is the efficacy of digital cognitive behavioral therapy for insomnia (CBT-I) versus digital sleep…
San Francisco, California
Primary Care-based Study of an Online Workshop for Family Caregivers of PLWD
open to eligible people ages 18 years and up
Many family and friend caregivers of persons living with dementia experience depression, stress, and other adverse health consequences due to the responsibilities of their caregiving role. These caregivers express a desire for education and support. …
San Francisco, California and other locations
Probiotic Administration for Adolescent Depression
open to eligible people ages 15-24
This double-blind, placebo-controlled clinical trial will examine the effect of probiotic Visbiome on the brain and gut microbiome of individuals 15 to 24 years of age.
San Francisco, California
Psilocybin Therapy for Depression in Parkinson's Disease
open to eligible people ages 40-80
The purpose of this study is to understand whether people with Parkinson's Disease and depression have improvement in their symptoms after psilocybin therapy.
San Francisco, California
The Reducing Risk Study
open to eligible people ages 12-18
The present study will test an innovative mobile health adaptation of a behavioral intervention that improves sleep and mental health concerns among adolescents.
San Francisco, California
Treating Major Depression With Yoga Mono-therapy
open to eligible people ages 18 years and up
The goal of this single-center, single-blind, randomized, controlled, parallel group, interventional trial is to evaluate antidepressant efficacy of yoga monotherapy of 12-weeks duration in 180 adults meeting diagnostic criteria for mild-to-moderate …
San Francisco, California
Electrophysiology to Index Non-invasive Brain Stimulation Effects on Reward System Functioning in Depression
open to eligible people ages 18-65
Depression is a leading cause of morbidity and mortality, conferring substantial healthcare and societal costs. By studying methods to non-invasively target neural circuitry involved in reward responsivity, information generated by this project will …
San Francisco, California
Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression Project
open to eligible people ages 65 years and up
The purpose of this research study is to characterize the mechanisms contributing to cognitive impairment and accelerated cognitive decline in Late Life Depression (LLD). This is a non-randomized, observational, non-treatment study that originally…
San Francisco, California and other locations
Reward Processing and Depressive Subtypes: Identifying Neural Biotypes
open to eligible people ages 18-70
Deficits in motivation and pleasure are common in depression, and thought to be caused by alterations in the ways in which the brain anticipates, evaluates, and adaptively uses reward-related information. However, reward processing is a complex,…
San Francisco, California
Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
Sorry, not currently recruiting here
The purpose of this study is to examine the efficacy, safety, and tolerability of CYB003 compared to matching placebo as adjunctive treatment in participants with MDD.
San Francisco, California and other locations
Neuroimaging Study of Open-label Placebo in Depressed Adolescents
Sorry, in progress, not accepting new patients
Major depressive disorder (MDD) is the current leading cause of disability worldwide and adolescence is an especially vulnerable period for the onset of depression. Non-pharmacologic approaches are particularly attractive as treatment of adolescent…
San Francisco, California
Attachment and Biobehavioral Catch-up and Depression Treatment
Sorry, in progress, not accepting new patients
Maternal depression influences the development of children's behavior problems and vice versa; however most interventions singularly address maternal depression or children's behavior problems rather than both. This project assesses the efficacy of…
San Francisco, California
By Youth, For Youth: Digital Supported Peer Navigation for Addressing Child Mental Health Inequities
Sorry, not yet accepting patients
Black and Latino youth are more likely to experience an unmet mental health or psychosocial need than do their white counterparts. Schools and primary care clinics are ideal hubs to provide mental health, healthcare, social services, and prevention…
Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disorder (MND) in Persons With HIV
Sorry, not yet accepting patients
A phase II, randomized, open-label, two-arm clinical trial evaluating the safety and efficacy of pramipexole extended release (ER) versus escitalopram for the treatment of major depressive disorder (MDD) and comorbid MDD with mild neurocognitive…
San Francisco, California and other locations
Precision Care for Major Depressive Disorder
Sorry, accepting new patients by invitation only
This study aims to assess whether phenotyping-guided intervention selection is superior to intervention selection without phenotyping guidance (i.e., routine clinician and patient judgment regarding treatment selection) for depression.
San Francisco, California
Psilocybin Therapy for Depression in Bipolar II Disorder
Sorry, in progress, not accepting new patients
The purpose of this study is to determine the safety, tolerability, and feasibility of psilocybin therapy in people with Bipolar II Disorder.
San Francisco, California
Spatiotemporal Dynamics of the Human Emotion Network
Sorry, accepting new patients by invitation only
The overall goal of this study is to elucidate how emotion network dynamics relate to the behavioral, autonomic, and experiential changes that accompany emotions and to investigate how emotion network dysfunction relates to affective symptoms.…
San Francisco, California
Supporting Peer Interactions to Expand Access to Digital Cognitive Behavioral Therapy for Spanish-speaking Patients
Sorry, accepting new patients by invitation only
Investigators will evaluate the implementation of an evidence-based, Spanish-language, digital, cognitive-behavioral therapy intervention (SilverCloud) in primary care settings for Latino patients with depression and/or anxiety. 426 participants…
San Francisco, California and other locations
SKY Breath Intervention
Sorry, in progress, not accepting new patients
Depression is highly debilitating and prevalent among adolescents. Adolescent-onset depression is associated with long, severe, and recurrent episodes that are often not responsive to treatment. There is a dire need to develop novel treatments that…
San Francisco, California
Our lead scientists for Depression research studies include Edward F Chang, MD Linda Pfiffner Scott Mackin, Ph.D. Arthur Wallace, MD, PhD Veronica Yank, MD Sudha Prathikanti, MD Owen Wolkowitz, MD Duygu Tosun, Ph.D. Joshua Woolley Susanna L Fryer, PhD Sabrina Darrow, MD Tony Yang Victoria Tang, MD, MAS Ellen R Bradley, MD Riley Bove, MD Jennifer N Felder, PhD Cherry Leung, PhD, RN Lauren Asarnow, PhD Ryan Rampersaud, MD, PhD Andrew Krystal Virginia Sturm, PhD Miriam Kuppermann, PhD, MPH.
Last updated: