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Depression clinical trials at UCSF

31 in progress, 20 open to eligible people

Showing trials for
  • Closed Loop, Doctor to Patient, Mobile Application for Depression in People With Multiple Sclerosis

    open to eligible people ages 18-80

    The researchers want to find out if an electronic application called MS CATCH can enhance patients' and doctors' experiences during and in between clinical visits. MS CATCH is a smartphone-based tool which allows patients to enter their mood related …

    San Francisco, California

  • Better Sleep Study

    open to eligible people ages 12-18

    The overall aim of this proposal is a confirmatory efficacy trial sufficiently powered and designed to test the hypothesis that improving the relationship between biological circadian timing and waketime, a novel modifiable target, improves…

    San Francisco, California

  • Biomarkers of Depression and Treatment Response

    open to eligible people ages 18-70

    This study is a stratified, parallel-group, single-center study utilizing multimodal imaging techniques to identify biomarkers for Major Depressive Disorder (MDD). The study goal is to identify biomarkers for MDD and treatment response that can be…

    San Francisco, California

  • Building Resilience for Surgical Recovery

    open to eligible people ages 65 years and up

    The goal of this clinical trial is to test problem solving therapy (PST) in older adults who are undergoing major surgery. The main question it aims to answer is: What is the feasibility and acceptability of delivering PST to older surgical patients …

    San Francisco, California

  • Cellular Aging and Neurobiology of Depression Study

    open to eligible people ages 21-60

    We are conducting an eight week longitudinal study to learn if blood levels of certain naturally occurring compounds and genetic markers differ between patients with depression and healthy adults who are not depressed, and if any such differences…

    San Francisco, California

  • Closed-Loop Deep Brain Stimulation for Major Depression

    open to eligible people ages 22-70

    Neurons are specialized types of cells that are responsible for carrying out the functions of the brain. Neurons communicate with electrical signals. In diseases such as major depression this electrical communication can go awry. One way to change…

    San Francisco, California

  • Diet and Depression

    open to eligible people ages 18-80

    This study is a pilot open label crossover trial to assess the feasibility and acceptability of reducing ultra- processed foods (UPF) in a personalized manner from the diets of patients with major depressive disorder who eat a large percentage of…

    San Francisco, California

  • Engaging Mothers & Babies; Reimagining Antenatal Care for Everyone (EMBRACE) Study

    open to eligible females

    This is a randomized comparative effectiveness study of two forms of enhanced prenatal care among 657 Medi-Cal eligible pregnant individuals in Fresno, California. The goal is to see whether group prenatal care with wrap around services versus…

    San Francisco, California and other locations

  • Ketamine for Veterans With Parkinson's Disease

    open to eligible people ages 40-80

    Parkinson's disease (PD) is a devastating illness that has a growing impact on Veterans. One of the most disabling symptoms is depression, which is common in PD and linked to poor quality of life and higher risk of suicide. Unfortunately, there is a …

    San Francisco, California

  • Near Infrared Spectroscopy (NIRS) for Assessment of Depression

    open to eligible people ages 18 years and up

    Develop a NIRSIT testing protocol that can be administered in the diagnostic setting and reliably distinguishes the symptoms and severity of depression, with the help of repeated measure (up to five visits per subject) comparison of patients being…

    San Francisco, California

  • Neural Mechanisms of Meditation Training in Healthy and Depressed Adolescents: An MRI Connectome Study PART 2

    open to eligible people ages 14-18

    The primary objective will be to study changes in putamen connectivity and depression severity in depressed teens with meditation training. H1: Putamen node strength will increase in the training group compared to the active controls. H2: This…

    San Francisco, California

  • Perinatal Research on Improving Sleep and Mental Health

    open to eligible females ages 18 years and up

    The goal of this clinical trial is to compare two sleep programs in pregnant people with insomnia. The main questions it aims to answer are: 1. What is the efficacy of digital cognitive behavioral therapy for insomnia (CBT-I) versus digital sleep…

    San Francisco, California

  • Primary Care-based Study of an Online Workshop for Family Caregivers of PLWD

    open to eligible people ages 18 years and up

    Many family and friend caregivers of persons living with dementia experience depression, stress, and other adverse health consequences due to the responsibilities of their caregiving role. These caregivers express a desire for education and support. …

    San Francisco, California and other locations

  • Probiotic Administration for Adolescent Depression

    open to eligible people ages 15-24

    This double-blind, placebo-controlled clinical trial will examine the effect of probiotic Visbiome on the brain and gut microbiome of individuals 15 to 24 years of age.

    San Francisco, California

  • Psilocybin Therapy for Depression in Parkinson's Disease

    open to eligible people ages 40-80

    The purpose of this study is to understand whether people with Parkinson's Disease and depression have improvement in their symptoms after psilocybin therapy.

    San Francisco, California

  • The Reducing Risk Study

    open to eligible people ages 12-18

    The present study will test an innovative mobile health adaptation of a behavioral intervention that improves sleep and mental health concerns among adolescents.

    San Francisco, California

  • Treating Major Depression With Yoga Mono-therapy

    open to eligible people ages 18 years and up

    The goal of this single-center, single-blind, randomized, controlled, parallel group, interventional trial is to evaluate antidepressant efficacy of yoga monotherapy of 12-weeks duration in 180 adults meeting diagnostic criteria for mild-to-moderate …

    San Francisco, California

  • Electrophysiology to Index Non-invasive Brain Stimulation Effects on Reward System Functioning in Depression

    open to eligible people ages 18-65

    Depression is a leading cause of morbidity and mortality, conferring substantial healthcare and societal costs. By studying methods to non-invasively target neural circuitry involved in reward responsivity, information generated by this project will …

    San Francisco, California

  • Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression Project

    open to eligible people ages 65 years and up

    The purpose of this research study is to characterize the mechanisms contributing to cognitive impairment and accelerated cognitive decline in Late Life Depression (LLD). This is a non-randomized, observational, non-treatment study that originally…

    San Francisco, California and other locations

  • Reward Processing and Depressive Subtypes: Identifying Neural Biotypes

    open to eligible people ages 18-70

    Deficits in motivation and pleasure are common in depression, and thought to be caused by alterations in the ways in which the brain anticipates, evaluates, and adaptively uses reward-related information. However, reward processing is a complex,…

    San Francisco, California

  • Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

    Sorry, not currently recruiting here

    The purpose of this study is to examine the efficacy, safety, and tolerability of CYB003 compared to matching placebo as adjunctive treatment in participants with MDD.

    San Francisco, California and other locations

  • Neuroimaging Study of Open-label Placebo in Depressed Adolescents

    Sorry, in progress, not accepting new patients

    Major depressive disorder (MDD) is the current leading cause of disability worldwide and adolescence is an especially vulnerable period for the onset of depression. Non-pharmacologic approaches are particularly attractive as treatment of adolescent…

    San Francisco, California

  • Attachment and Biobehavioral Catch-up and Depression Treatment

    Sorry, in progress, not accepting new patients

    Maternal depression influences the development of children's behavior problems and vice versa; however most interventions singularly address maternal depression or children's behavior problems rather than both. This project assesses the efficacy of…

    San Francisco, California

  • By Youth, For Youth: Digital Supported Peer Navigation for Addressing Child Mental Health Inequities

    Sorry, not yet accepting patients

    Black and Latino youth are more likely to experience an unmet mental health or psychosocial need than do their white counterparts. Schools and primary care clinics are ideal hubs to provide mental health, healthcare, social services, and prevention…

  • Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disorder (MND) in Persons With HIV

    Sorry, not yet accepting patients

    A phase II, randomized, open-label, two-arm clinical trial evaluating the safety and efficacy of pramipexole extended release (ER) versus escitalopram for the treatment of major depressive disorder (MDD) and comorbid MDD with mild neurocognitive…

    San Francisco, California and other locations

  • Precision Care for Major Depressive Disorder

    Sorry, accepting new patients by invitation only

    This study aims to assess whether phenotyping-guided intervention selection is superior to intervention selection without phenotyping guidance (i.e., routine clinician and patient judgment regarding treatment selection) for depression.

    San Francisco, California

  • Psilocybin Therapy for Depression in Bipolar II Disorder

    Sorry, in progress, not accepting new patients

    The purpose of this study is to determine the safety, tolerability, and feasibility of psilocybin therapy in people with Bipolar II Disorder.

    San Francisco, California

  • Spatiotemporal Dynamics of the Human Emotion Network

    Sorry, accepting new patients by invitation only

    The overall goal of this study is to elucidate how emotion network dynamics relate to the behavioral, autonomic, and experiential changes that accompany emotions and to investigate how emotion network dysfunction relates to affective symptoms.…

    San Francisco, California

  • Supporting Peer Interactions to Expand Access to Digital Cognitive Behavioral Therapy for Spanish-speaking Patients

    Sorry, accepting new patients by invitation only

    Investigators will evaluate the implementation of an evidence-based, Spanish-language, digital, cognitive-behavioral therapy intervention (SilverCloud) in primary care settings for Latino patients with depression and/or anxiety. 426 participants…

    San Francisco, California and other locations

  • Telepsychology in Spinal Cord Injury

    Sorry, in progress, not accepting new patients

    This study will determine the effectiveness of tele-psychology in treating persons with spinal cord injury (SCI) with depressed mood in the early period post-rehabilitation discharge. Depression among individuals with SCI is the most common…

    San Jose, California

  • SKY Breath Intervention

    Sorry, in progress, not accepting new patients

    Depression is highly debilitating and prevalent among adolescents. Adolescent-onset depression is associated with long, severe, and recurrent episodes that are often not responsive to treatment. There is a dire need to develop novel treatments that…

    San Francisco, California

Our lead scientists for Depression research studies include .

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