for females ages 2 years and up (full criteria)
Healthy Volunteers
healthy people welcome
at San Francisco, California
study started
completion around
Principal Investigator
by Danielle Roubinov
Headshot of Danielle Roubinov
Danielle Roubinov



Maternal depression influences the development of children's behavior problems and vice versa; however most interventions singularly address maternal depression or children's behavior problems rather than both. This project assesses the efficacy of an intervention that treats both mothers and children in an integrated manner. Effects are expected to disrupt the reciprocal relations that perpetuate maternal and child mental health problems over time.

Official Title

Efficacy of an Integrated Intervention to Treat Maternal Depression and Children's Behavior Problems: A Transactional Perspective


The proposed project is a pilot randomized controlled trial to evaluate the effectiveness of an integrated intervention that dually treats maternal depressive symptoms and offspring behavior problems. Families (n = 40 mothers and their 2-to-4 year-old children) will be randomized to receive 10 sessions of ABC or 10 sessions of ABC+D in their home. ABC+D is an expanded version of ABC that additionally treats maternal depressive symptoms using Mothers and Babies adapted for mothers of toddlers. The specific aims of this proposed project are:

Aim 1. Collect preliminary data on the feasibility and acceptability of ABC+D in preparation for a small pilot randomized controlled trial (RCT).

Aim 2. Conduct a small pilot RCT to examine the effectiveness of ABC and ABC+D

Aim 3: Assess the overall acceptability (mother- and provider-rated), appropriateness (mother- and provider-rated), and feasibility (provider-rated) of ABC+D. Mothers will also rate their satisfaction with each session and the degree to which it was helpful, interesting, and comprehensible.


Maternal Depression, Child Behavior Problem, Depression, Depressive Disorder, Problem Behavior, Attachment and Biobehavioral Catch up, Attachment and Biobehavioral Catch up Plus Depression Treatment, ABC+D


You can join if…

Open to females ages 2 years and up

  1. Mothers 18 years of age or older with heightened depressive symptoms as determined by a score of 5 or higher on the Patient Health Questionnaire-9 (PHQ-9)
  2. Biological children (of mothers described above) between 2 and 4 years old with heightened behavior problems as determined by a score of at least 3 in at least 1 domain of functioning on the Impairment Rating Scales
  3. English- or Spanish-speaking

You CAN'T join if...

  1. Self-reported history of psychosis or active suicidality as defined by self-report of a specific suicide plan or recent attempt
  2. Child diagnosis of autism


  • UCSF
    San Francisco California 94118 United States

Lead Scientist at UCSF

  • Danielle Roubinov
    Assistant Professor, Psychiatry, School of Medicine. Authored (or co-authored) 69 research publications


in progress, not accepting new patients
Start Date
Completion Date
University of California, San Francisco
Study Type
About 76 people participating
Last Updated