for males ages 18 years and up (full criteria)
at San Francisco, California
study started
estimated completion:
William Woods



In the era of HIV treatment as prevention (TasP), efforts are needed to identify evidence-based combination prevention approaches that achieve greater decreases HIV viral load among populations that are more likely to engage in HIV transmission risk behavior. Because methamphetamine-using men who have sex with men (MSM) are at greater risk for acquiring and transmitting medication-resistant strains of HIV, interventions targeting stimulant use in this population of high-risk men could boost the effectiveness of TasP. At present, only conditional cash transfer approaches such as contingency management (CM) have demonstrated short- term efficacy in reducing stimulant use among substance-using MSM who are not actively seeking formal treatment. The proposed RCT will examine the efficacy of a positive affect intervention that is designed to optimize the effectiveness of CM to achieve long-term reductions in stimulant use and HIV viral load in this population. the investigators' team will examine the efficacy of this integrative intervention in a randomized controlled trial (RCT) with 230 HIV-positive, methamphetamine-using MSM. After enrolling in CM, participants will be randomized to receive either: 1) the positive affect intervention; or 2) a attention-matched control condition. Follow-up data will be collected at 3, 6, and 12 months post-randomization. This RCT will provide an opportunity to examine the efficacy of an integrative intervention designed to promote long-term reductions in HIV viral load as the primary outcome. Secondary outcomes that will be examined include: increases positive affect, reductions in stimulant use, improvements in T-helper (CD4+) count, and decreases HIV transmission risk behavior. Identifying an efficacious intervention approach to decrease HIV viral load among methamphetamine-using MSM would substantially support the goals of the National HIV/AIDS Strategy to reduce HIV incidence and mitigate HIV-related health disparities.

Official Title

Randomized Controlled Trial of an Integrative Intervention for Non-Treatment-Seeking Meth Users


HIV/AIDS Stimulant Use Disorders Treatment as Prevention Methamphetamine Cocaine HIV viral Load Affect Regulation Treatment to Enhance Meth Intervention Success (ARTEMIS) Contingency Management (CM) ARTEMIS+CM


You can join if…

Open to males ages 18 years and up

  • At least 18 years old
  • Documentation of HIV-positive serostatus
  • Speak English
  • Biological verification of recent methamphetamine use
  • Completion of at least three contingency management (CM) visits
  • Self reported anal sex with a man (MSM) in the past 12 months

You CAN'T join if...

  • Inability to provide informed consent, evidenced by cognitive impairment
  • HIV negative serostatus


  • Alliance Health Project
    San Francisco California 94102 United States


in progress, not accepting new patients
Start Date
Completion Date
University of California, San Francisco
Community-Based Partner for Contingency Management
Lead Scientist
William Woods
Study Type
Last Updated