RATIONALE: Collecting and storing samples of blood from patients with cancer to study in the laboratory may help doctors learn more about how patients respond to treatment with certain chemotherapy drugs.
PURPOSE: This laboratory study is looking at the pharmacokinetics of daunorubicin in treating young patients with cancer.
Pharmacokinetics of Daunomycin in Children
Determine the pharmacokinetics of daunorubicin hydrochloride in pediatric patients with malignancy.
Evaluate the relationship between body composition (percent body fat) and the pharmacokinetics of daunorubicin hydrochloride in these patients.
Correlate the pharmacokinetics of daunorubicin hydrochloride with gender, age, or ethnic background in these patients.
Explore, in a preliminary fashion, possible relationships between pharmacokinetic results and toxicity.
Explore, in a preliminary fashion, possible relationships between pharmacokinetic results and renal and hepatic function and complete blood count.
Explore, in a preliminary fashion, possible genetic polymorphisms that may influence daunorubicin hydrochloride disposition.
OUTLINE: This is a multicenter study.
Patients undergo blood collection prior to, periodically during, and after treatment with daunorubicin hydrochloride for pharmacokinetic analysis.
Patients also undergo body composition testing within 7 days before or after the administration of daunorubicin hydrochloride using dual-energy x-ray absorptiometry.
PROJECTED ACCRUAL: A total of 100 patients will be accrued for this study.
Must be receiving a chemotherapy regimen that includes daunorubicin hydrochloride administered as an infusion of any duration for < 24 hours on either a 1- or a 2-day schedule, including bolus and all short infusion schedules
Not pregnant or nursing
No significant uncontrolled systemic illness
Large implanted prostheses allowed (should not undergo dual energy x-ray absorptiometry scan)
PRIOR CONCURRENT THERAPY:
See Disease Characteristics
UCSF Helen Diller Family Comprehensive Cancer Center San Francisco, California, 94115, USA
Stanford Cancer Center Stanford, California, 94305, USA
Childrens Hospital Los Angeles Los Angeles, California, 90027, USA
Children's Hospital of Orange County Orange, California, 92868, USA