Summary

Eligibility
for people ages 18 years and up (full criteria)
Location
at San Francisco, California and other locations
Dates
study started
completion around

Description

Summary

This is a Phase 1/2, open-label, first-in-human (FIH) study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and anticancer activity of BLU-222, a selective inhibitor of CDK2.

Official Title

A Phase 1/2 Study to Evaluate the Safety, Pharmacokinetics, and Efficacy of BLU-222 as a Single Agent and in Combination Therapy for Patients With Advanced Solid Tumors

Keywords

Advanced Solid Tumors, HR+ Breast Cancer, CCNE1 Amplification, HER2-negative Breast Cancer, Ovarian Cancer, Endometrial Cancer, Gastric Cancer, Esophageal Adenocarcinoma, Carcinosarcoma, CDK2, CCNE1, Platinum-resistance, Platinum-refractory, CDK4/6i, Ribociclib, Carboplatin, Fulvestrant, ER+ Breast Cancer, Breast Neoplasms, Endometrial Neoplasms, Mullerian Mixed Tumor, BLU-222, BLU-222 Monotherapy, BLU-222 + Carboplatin, BLU-222 + Ribociclib + Fulvestrant, BLU-222 + Fulvestrant

Eligibility

You can join if…

Open to people ages 18 years and up

  1. Advanced solid tumors that has progressed beyond standard of care OR
  2. HR+ HER2- BC that has progressed following treatment with a CDK4/6 inhibitor OR
  3. Endometrial and gastric cancer that has progressed after at least 2 prior therapies (including one prior platinum therapy) OR
  4. Platinum refractory or platinum resistant ovarian cancer CCNE1 amplified tumors that have progressed beyond standard of care

You CAN'T join if...

  1. Have visceral crisis, lymphangitic spread, or leptomeningeal carcinomatosis.
  2. Have received the following anticancer therapy:
    1. Previous therapy with CDK2i, PKMYT1i, or WEE1i, except in Part 1A where up to 10 patients who previously received PKMYT1i, or WEE1 inhibitor will be permitted.
  3. Have central nervous system (CNS) metastases or spinal cord compression that is associated with progressive neurological symptoms or requires increasing doses of corticosteroids to control the CNS disease.
  4. Have known intracranial hemorrhage and/or bleeding diatheses.
  5. Have clinically active ongoing ILD of any etiology, including drug-induced ILD, and radiation pneumonitis within 28 days prior to initiation of study treatment.
  6. Have any unresolved toxicities from prior therapy greater than CTCAE Grade 1 or that have not resolved to baseline at the time of starting the study.
  7. Have mean resting QTcF > 450 msec in men or QTcF > 470 msec in women, a history of prolonged QT syndrome or Torsades de pointes, or a familial history of prolonged QT syndrome.
  8. Have clinically significant, uncontrolled, cardiovascular disease including congestive heart failure Grade III or IV according to the New York Heart Association classification; myocardial infarction or unstable angina within the previous 6 months, uncontrolled hypertension, or clinically significant, uncontrolled arrhythmias, including bradyarrhythmia that may cause QT prolongation (eg, Type II second degree heart block or third-degree heart block).
  9. Have a history of another primary malignancy other than completely resected carcinomas in situ) that has been diagnosed or required therapy within 2 years prior to initiation of study treatment.

    10. Have known active, uncontrolled infection (viral, bacterial, or fungal), including

    tuberculosis, hepatitis B virus (HBV), hepatitis C virus, AIDS-related illness, or COVID-19 infection (symptoms and a positive test result).

    11. Requires treatment with a prohibited medication or herbal remedy that cannot be

    discontinued at least 2 weeks before the start of study drug administration.

    12. Have planned major surgical procedure within 14 days of the first dose of study drug

    (procedures such as central venous catheter placement, tumor needle biopsy, and feeding tube placement are not considered major surgical procedures).

    13. Unwilling or unable to comply with scheduled visits, study drug administration plan,

    laboratory tests, or other study procedures and study restrictions.

    14. Patient is a woman who is not postmenopausal or surgically sterile, and is unwilling

    to abstain from sexual intercourse or employ highly effective contraception OR is a man who is not surgically sterile, and is unwilling to abstain from sexual intercourse or employ highly effective contraception

    15. Patient is a pregnant female

Locations

  • UCSF Helen Diller Family Comprehensive Cancer Center accepting new patients
    San Francisco California 94158 United States
  • University of Utah - Huntsman Cancer Institute - PPDS accepting new patients
    Salt Lake City Utah 84112 United States

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Blueprint Medicines Corporation
ID
NCT05252416
Phase
Phase 1/2 research study
Study Type
Interventional
Participants
Expecting 366 study participants
Last Updated